Aging of the organism is associated with highly reproducible DNA methylation (DNAm) changes, which facilitate estimation of donor age. Cancer is also associated with DNAm changes, which may contribute to disease development. Here, we speculate that age‐associated DNAm changes may increase the risk of tumor initiation. Notably, when using epigenetic signatures for age‐estimations tumor cells are often predicted to be much older than the chronological age of the patient. We demonstrate that aberrant hypermethylation within the gene DNA methyltransferase 3A (DNMT3A) (...) – which may contribute to initiation of acute myeloid leukemia (AML) – is particularly observed in AML samples that reveal significantly more age‐associated DNAm changes. The functional relevance of age‐associated DNAm changes remains to be elucidated, but they occur genome wide, in a highly reproducible manner, and most likely influence chromatin organization – and hence may favor acquisition of aberrant DNAm patterns contributing to cancer in the elderly. (shrink)

This essay deals with some philosophical problems concerning the understanding of ethical conceptions in an alien culture. Its aim is to show that in investigating such conceptions we cannot proceed on purely empirical grounds; our own ethical concepts will, in a conceptual sense, determine what it is conceivable that we find.

Social enterprises, like almost all organizations, continuously strive for external legitimacy. To be perceived as externally legitimated by society, social enterprises often engage in strategic partnerships. However, scholars have only recently turned their attention to the legitimating function of such partnerships. The purpose of this article is to address the hitherto neglected construct of inter-partner legitimacy. Drawing on institutional theory, we hypothesize that such inter-partner legitimacy affects the resource transfer among partners, which will, in turn, be recognized by society and (...) will subsequently affect each partner’s external legitimacy. Dyadic data of 121 strategic partnerships between social enterprises and their key partners confirm our hypotheses. We add to institutional theory by integrating the often ignored dimension of inter-partner legitimacy into our analysis and demonstrate its relevance to each partner’s external legitimacy and to resource transfer. Further contributions to the literature on institutional theory, legitimacy, social entrepreneurship, and inter-organizational relationships are identified. (shrink)

This essay is a critical discussion of Dipesh Chakrabarty’s book Provincializing Europe as well as a first sketch of a History on Equal Terms. After giving a short summary of Provincializing Europe, I first argue, against Chakrabarty, that there is no necessary connection between the discipline of history and the metanarratives of modernity. To the contrary: the founding idea of the discipline of history was a turn against such grand narratives. With his attempt to deconstruct the narratives of the European (...) Enlightenment and of modernity, Chakrabarty therefore has to be regarded as a thinker of radical historicism rather than as a critic of the discipline of history. Second, I criticize the use of the term “modernity” in Provincializing Europe and the concept of modernity in general. Instead of a deconstruction of the discipline of history, I propose a deconstruction of the concept of modernity. This could open up the way for a History on Equal Terms situated within the discipline of history, that is, a historiography that would—just as Chakrabarty rightly demands—in principle pay the same attention to and expect relevant results from any region in the world, depending only on the focus of research. (shrink)

According to Alexius Meinong, in order to give a philosophical explanation of the world we need to consider both existent and nonexistent objects, lest we fall into the "prejudice in favour of the real". The paper starts by examining some basic concepts of object theory seen as an existence-free science (modes of being, principle of independence of so-being from being, "Aussersein" and Meinong's paradox). There follows an exposition of Bertrand Russell's position, characterized by a "robust sense of reality", and afterwards (...) an analysis of differences and similarities between the two philosophers. The paper ends with a short account of Meinongian semantics and a comparison between object theory and metaphysics. (shrink)

The purpose of this article is to discuss narration of ethical themes in nursing care. The text represents part of the findings of an ethnographic study aimed at description of everyday work on an oncology ward. Nurses on this ward are constantly involved in ethical care issues and narratives are told to share experiences. Of vital importance in ethical decision making is the perpetual creation of a mediating moral world constituted by daily experience. The need for making space in nursing (...) for a continual learning conversation is expressed and in this I include writings of nursing theorists. (shrink)

“Naturalismo” è una parola che si dice in molti modi, almeno tanti quanti nella storia della filosofia e nel sentire comune sono i modi in cui si è parlato di “natura” e di espressioni simili. Oggi, il tema del naturalismo in filosofia e della cosiddetta naturalizzazione che una filosofia dovrebbe eventualmente attrezzare determinate nozioni e teorie è tornato prepotentemente alla ribalta della riflessione filosofica, sulla scia dei successi provenienti dalle scienze cognitive (linguistica, n...

“Naturalismo” è una parola che si dice in molti modi, almeno tanti quanti nella storia della filosofia e nel sentire comune sono i modi in cui si è parlato di “natura” e di espressioni simili. Oggi, il tema del naturalismo in filosofia e della cosiddetta naturalizzazione che una filosofia dovrebbe eventualmente attrezzare determinate nozioni e teorie è tornato prepotentemente alla ribalta della riflessione filosofica, sulla scia dei successi provenienti dalle scienze cognitive (linguistica, n...

“Naturalismo” è una parola che si dice in molti modi, almeno tanti quanti nella storia della filosofia e nel sentire comune sono i modi in cui si è parlato di “natura” e di espressioni simili. Oggi, il tema del naturalismo in filosofia e della cosiddetta naturalizzazione che una filosofia dovrebbe eventualmente attrezzare determinate nozioni e teorie è tornato prepotentemente alla ribalta della riflessione filosofica, sulla scia dei successi provenienti dalle scienze cognitive (linguistica, n...

Nel 1856 Madame Bovary esce a puntate sulla «Revue de Paris» (1° ottobre - 15 dicembre), per comparire poi in versione integrale un anno dopo – in seguito all’assoluzione di Gustave Flaubert, avvenuta il 7 febbraio – presso l’editore Lévy. Il titolo dell’opera, molto semplice, è decisamente in linea con il realismo: l’autore si mette da parte, rinunciando alla propria voce e alla propria opinione, per fare parlare direttamente i personaggi e gli eventi che li riguardano. Infatti il titolo non...

Il cosiddetto “paradosso della finzione” nasce dal tentativo di spiegare quale tipo di emozioni proviamo verso quegli oggetti che troviamo nei romanzi e nei film e che sappiamo perfettamente essere fittizi. Si tratta di un paradosso classico, tornato alla ribalta nel 1975 dopo la pubblicazione di un articolo di Colin Radford che partiva precisamente dall’interrogativo riguardante le lacrime che versiamo per ciò che non è reale (come un personaggio fittizio, appunto). Perché ci commuoviamo per il suicidio di Anna Karenina se (...) sappiamo che non esiste? Che differenza c’è tra piangere per Anna Karenina, piangere per una bugia, piangere per la depressione e fare finta di piangere perché si vuol fare credere a chi ci guarda che siamo sinceramente commossi? In Piangere e ridere davvero (2009) Maurizio Ferraris offre un’interessante proposta teorica per dissolvere il paradosso in questione e si sofferma su alcune distinzioni fondamentali riguardanti le nostre reazioni emotive a stimoli reali e fittizi. In questo saggio si prende spunto dalla teoria di Ferraris e ci si propone di chiarire che cosa significhi fare finta di rispondere emotivamente a qualcosa nella vita di tutti i giorni e quale sia la differenza tra queste “finte” emozioni e quelle che invece proviamo durante la fruizione di opere che sappiamo essere di finzione. Saranno scelti come esempi paradigmatici il caso Fenaroli (al centro della cronaca italiana alla fine degli anni Cinquanta), Il vedovo di Dino Risi e Scusate il ritardo di Massimo Troisi. (shrink)

According to Paolo D’Angelo my Philosophy of Literature actually is an Analytical Philosophy of Literature. His main worry does not concern simply the title, but the fact of my having consciously excluded some authors just because, he maintains, they are not analytic philosophers. In this note I try to explain my reasons together with a defense of philosophy of literature in its own peculiarity distinguishing it from literary criticism, literature in philosophy and philosophy as literature.

What happens us emotionally when we read a work of fiction? According to some philosophers our emotional engagement with fiction gives rise to a paradox and involves either irrationality or participation in a game of make believe. I argue that an Object Theory in a meinongian style, by supporting a realistic perspective on fictional emotions, is able to dissolve the paradox of fiction by providing a positive ontological account of fictional entities (and the properties characterizing them).

The anti-fascist cantata Il canto sospeso, the string quartet Fragmente - Stille, an Diotima and the 'Tragedy of Listening' Prometeo cemented Luigi Nono's place in music history. In this study, Carola Nielinger-Vakil examines these major works in the context of Nono's amalgamation of avant-garde composition with Communist political engagement. Part I discusses Il canto sospeso in the context of all of Nono's anti-fascist pieces, from the unfinished Fučik project to Ricorda cosa ti hanno fatto in Auschwitz. Nielinger-Vakil explores Nono's (...) position at the Darmstadt Music Courses, the evolution of his compositional technique, his penchant for music theatre and his use of spatial and electronic techniques to set the composer and his works against the diverging circumstances in Italy and Germany after 1945. Part II further examines these concerns and shows how they live on in Nono's work after 1975, culminating in a thorough analysis of Prometeo. (shrink)

Este artículo sintetiza algunos aspectos del proyecto “Hierro y bronce. Criterios para la valoración y conservación de la herrería artística en el patrimonio arquitectónico del Uruguay”[i], cuyo objetivo es establecer los atributos patrimoniales de los elementos ornamentales metálicos asociados a fachadas del patrimonio arquitectónico nacional y contribuir a su difusión, puesta en valor y conservación. A lo largo de la investigación se abordan los aspectos socioculturales, artísticos, formales, técnicos y, por último, los relativos al deterioro de estos elementos y las (...) pautas para su preservación y restauración. La metodología se basa en el estudio de fuentes primarias, éditas e inéditas, en la revisión de bibliografía especializada y en el trabajo de campo sobre una muestra representativa de elementos ornamentales metálicos aplicados a las fachadas de la arquitectura montevideana. Fue relevado un total de 250 edificios, correspondientes a los distintos períodos que distinguimos en la evolución de la herrería local entre finales del siglo XVIII y mediados del siglo XX. Se trata de un aporte inicial que profundiza en un campo escasamente abordado en nuestro medio acerca del conocimiento y difusión de los trabajos de herrería en el marco del patrimonio arquitectónico y artístico uruguayo, proporcionando información útil a la academia, las instituciones vinculadas a la valoración y conservación patrimonial y el público general. Notas [i] Proyecto concursado y financiado en la modalidad Investigación y Desarrollo (I+D), Comisión Sectorial de Investigación científica (CSIC), Universidad de la República, a realizarse entre marzo de 2018 y marzo de 2020, por un equipo interdisciplinario integrado por docentes e investigadores de las facultades de Arquitectura, Diseño y Urbanismo: Miriam Hojman, Valentina Marchese y Tatiana Rimbaud (Instituto de Historia), Gianella Mussio, Leticia Olivera, Carola Romay y Verónica Ulfe (Instituto de Tecnologías); de la Facultad de Humanidades y Ciencias de la Educación: Ernesto Beretta (Instituto de Ciencias Históricas-Historia del Arte); y de la Facultad de Ingeniería: Sofía Aguiar (Instituto de Ensayo de Materiales). El presente artículo fue elaborado por todos los integrantes del equipo. (shrink)

A decade in the making, the _Handbook i_s the definitive contemporary exposition of interpersonal psychoanalysis. It provides an authoritative overview of development, psychopathology, and treatment as conceptualized from the interpersonal viewpoint.

Durante la edad escolar, los sujetos van logrando una madurez sintáctica, evidenciada en el incremento de lacomplejidad estructural de los textos que producen. Diversas teorías han dado cuenta de dicha complejidad(Hunt, 1970; Katzenberger, 2004; Nir & Berman, 2010), sosteniendo que la misma está vinculada con eltipo de relaciones interclausulares dentro del texto. Asimismo, corroboran que dicha complejidad no sólo seincrementa con el nivel educativo, sino también está guiada por la modalidad discursiva. A partir de estapropuesta, el proyecto FONDECYT 1100600, se (...) planteó el objetivo de describir el desarrollo de la sintaxisoral, considerando otra perspectiva de la complejidad: la diversidad interclausular. Para ello, se aplicarondos tareas de elicitación (narración y explicación), a 250 estudiantes de kinder, 3º y 6º básico, Iº y IVº mediode Valparaíso y Santiago. Luego de ser transcritos y analizados, se reconocieron en los textos las relacionesinterclausulares y se estableció un índice de diversidad clausular, en el entendido de que a medida que seusaban más formas para relacionar las cláusulas, mayor sería la complejidad sintáctica de los mismos. Losresultados muestran un incremento de la diversidad clausular a medida que aumenta el nivel educativo, sinembargo, su significatividad se da sólo entre algunos niveles. Además, entre ambos tipos de textos no semanifiestan grandes diferencias, salvo en Kínder y en IVº Medio. Estos hallazgos permiten vislumbrar que lamadurez sintáctica implica tener mayor cantidad de estructuras gramaticales y utilizarlas estratégicamentepara construir un determinado texto. (shrink)

This response to Carola Dietze’s critique of Provincializing Europe takes up for examination three key expressions or ideas on which the original argument of the book was founded: hyperreal Europe, historicism, and political modernity. I appreciate the spirit of Dietze’s engagement with the book, but I show that her critique is based on a degree of misapprehension of these three central ideas. While clarifying the details and the degree of my disagreement with Dietze, I provide my own critique of (...) Dietze’s proposal of “equal histories” by arguing that Dietze has not named or explained the unit with respect to which different histories could be considered equal. I also argue that Dietze’s proposals about judging societies only by their “own” standards, and basing human dignity on the idea of a “human nature” that could be seen as a “constant,” do not solve the problems she sees with my book and are themselves open to some serious historical and logical criticism. (shrink)

Cultural Intersections in Later Chinese Buddhism. Edited by Marsha Weidner. University of Hawai'i Press, Honolulu 2001. ix, 234 pp. US$44.00. ISBN 0-8248-2308-7.

ABSTRACTHow accurate are insights compared to analytical solutions? In four experiments, we investigated how participants' solving strategies influenced their solution accuracies across different types of problems, including one that was linguistic, one that was visual and two that were mixed visual-linguistic. In each experiment, participants' self-judged insight solutions were, on average, more accurate than their analytic ones. We hypothesised that insight solutions have superior accuracy because they emerge into consciousness in an all-or-nothing fashion when the unconscious solving process is complete, (...) whereas analytic solutions can be guesses based on conscious, prematurely terminated, processing. This hypothesis is supported by the finding that participants' analytic solutions included relatively more incorrect responses than timeouts compared to their insight responses. (shrink)

Una forma frecuente de medir y estimular el desarrollo narrativo infantil utiliza el recontado de una narración. En Chile, se han diseñado tareas considerando la estructura del input verbal, tanto en un nivel léxico-sintáctico como textual, estableciéndose –incluso– niveles de complejidad. En el marco del Proyecto FONDECYT 1130420, para elaborar un cuento infantil –input de la tarea de recontado– se hizo hincapié no solo en los rasgos verbales, sino también visuales del relato. De tal forma, se propuso un doble objetivo: (...) diseñar las imágenes de una historia potenciando su significado a través de una gramática visual y observar en qué medida estos elementos aparecen reflejados en el recontado oral de los sujetos. Para este propósito, junto a la Gramática de la Historia para el discurso, se consideró la Gramática de Diseño Visual y sus herramientas analíticas para la construcción de imágenes. El cuento se piloteó en una muestra de 20 pre-escolares de Kinder de un colegio particular subvencionado de la Región de Valparaíso. Sus discursos fueron videograbados, transcritos y analizados. Se observó que todas las imágenes narrativas aparecen mencionadas en más de un 60% de los recontados. Además, existen tres referidas en el 90% de los discursos infantiles y representan momentos cruciales del relato o cierta complejidad del input como la simultaneidad de acciones. Estos resultados permiten valorar la importancia de los elementos visuales del cuento en la tarea de recontado infantil. (shrink)

La inmunización en adultos es una estrategia de salud pública que se ha desarrollado e impulsado en los últimos años como consecuencia del envejecimiento poblacional. El aumento de la proporción de personas adultas en la población y la manifiesta preocupación por promover un envejecimiento saludable de la población plantean la premura de aportar evidencia científica sobre los factores que se asocian a la vacunación de adultos. La prevalencia de inmunizaciones en adultos está por debajo de las metas planteadas por el (...) Ministerio de Salud, por ello se propone como objetivo explorar e identificar los factores asociados a la vacunación de adultos en Argentina, teniendo en cuenta las recomendaciones del calendario nacional de inmunizaciones. Se trata de un estudio cuantitativo, exploratorio y correlacional, cuya fuente de datos es la Encuesta Nacional de Factores de Riesgo de 2013. En la metodología se desarrollan modelos logísticos individuales usando como variables explicativas sexo, nivel de instrucción, cobertura de salud, situación conyugal y si accedió a información sobre vacunas de adultos en algún medio masivo de comunicación. La unidad de análisis son las personas mayores de 18 años y se analizan las subpoblaciones objetivo de las siguientes vacunas: doble bacteriana o triple acelular del adulto, influenza y neumococo. Como contribución puede mencionarse que los resultados indican que haber visto o escuchado información sobre vacunas de adultos resultó el factor que más aumenta las probabilidades de estar inmunizados de los adultos argentinos. (shrink)

According to some, there is a problem concerning the emotions we feel toward fictional entities such as Anna Karenina, Werther and the like. We feel pity, fear, and sadness toward them, but how is that possible? “We are saddened, but how can we be? What are we sad about? How can we feel genuinely and involuntarily sad, and weep, as we do know that no one has suffered or died?” (Radford, in: Proceedings of the Aristotelian Society, 1975). This is the (...) paradox of fiction which is based on the assumption that emotions, to be genuine and rational, should be directed toward existent beings. But if beliefs about existence are necessary for us to be rationally moved by something, and such beliefs are lacking when we are moved by fiction (because we do not believe fictional characters and events to be real), then our capacity for an emotional response to fiction is irrational. Consequently, our emotional attitude toward future generations should be considered as irrational as well. But is this really the case? Are there good arguments to consider future and fictional entities as similar from this point of view? Or would it be better to distinguish the two? Is there such a thing as a paradox of the future? If so, how does it relate to the more famous paradox of fiction? (shrink)

When solving a problem with insight, people suddenly become aware of the solution (Mayer, 1995). Insight is often accompanied by a feeling of pleasure and certainty, known as an “Aha! moment” (Gick...

Augustine of Hippo understands the lay faithful in virtue of their regal-sacerdotal anointing at Baptism to exercise, always in unison with the ordained ministry, an indispensable twofold role in the sinner’s reconciliation. In Peter, not only the clergy but indeed all the saintly members of the community receive the spiritual commission to bind and loose. According to their particular vocation, the lay faithful bind the sinner through fraternal correction and loose him through their intercessory prayer. As members of the Totus (...) Christus, they participate in Christ’s unique remissive mediation. A mixed society where saints live among sinners provides the necessary context for this ecclesial reconciliation. (shrink)

This article is based on narrative, autobiographic interviews with domestic workers in Peru focusing on their migration and work experiences. The interviewees evoke a border discourse that divides and hierarchizes Peruvian society and stigmatizes migrants, especially migrant domestic workers. As domestic service leads to intense social interactions at this ‘border’, the interviewees are constantly forced to ‘translate’ when constructing their identity. The discourse-analytical bottom—up perspective focusing on membership categorization devices evaluates the performativity of the discourses of those considered as ‘oppressed’; (...) it analyses processes of subjection and subjectification: whereas some of the interviewees internalize the discursively attributed inferior ‘Me’, others use the constructed borders as an opportunity to develop hybrid discourse strategies that cross and even deconstruct social categorizations. By focusing on the agency of ‘border-crossers’, the article aims at scientifically ‘rethinking the social with cultural difference as a constitutive feature’. (shrink)

In this paper, we present some experimental findings whose best explanation, first of all, provides a positive answer to a philosophical question in ontology as to whether, in the overall domain of beings, there are fictional characters (_ficta_) over and above concrete individuals. Moreover, since such findings arise out of different comparisons between fictional characters and concrete individuals on the one hand and fictional characters again and non-items that do not belong at all to such an overall domain on the (...) other hand, they also suggest that _ficta_ are allowed as inhabiting a particular subrealm of that domain distinct from the one inhabited by concrete individuals, as previous findings in cognitive psychology had suggested. (shrink)

In diesem Beitrag werden die Fragen diskutiert: Welche Vorstellungen von Geschlecht und Sexualität finden sich im Buddhismus, welche Frauenrollen oder Frauenbilder lassen sich daraus ableiten, und was geschieht, wenn diese Geschlechtervorstellungen heute auf den europäischen Kontext treffen: Welche Probleme entstehen? Ist Geschlechtergerechtigkeit ein westliches Problem oder wird sie weltweit thematisiert? Lassen sich Wechselwirkungen feststellen, und welche Strategien werden verfolgt, um Geschlechtergerechtigkeit im Buddhismus herzustellen?

1. False information takes many shapes. While misinformation has long been a feature of conveying the human experience to others, the rise of the internet and social media has created conditions in...

A collection of papers presented at the First International Summer Institute in Cognitive Science, University at Buffalo, July 1994, including the following papers: ** Topological Foundations of Cognitive Science, Barry Smith ** The Bounds of Axiomatisation, Graham White ** Rethinking Boundaries, Wojciech Zelaniec ** Sheaf Mereology and Space Cognition, Jean Petitot ** A Mereotopological Definition of 'Point', Carola Eschenbach ** Discreteness, Finiteness, and the Structure of Topological Spaces, Christopher Habel ** Mass Reference and the Geometry of Solids, Almerindo E. (...) Ojeda ** Defining a 'Doughnut' Made Difficult, N .M. Gotts ** A Theory of Spatial Regions with Indeterminate Boundaries, A.G. Cohn and N.M. Gotts ** Mereotopological Construction of Time from Events, Fabio Pianesi and Achille C. Varzi ** Computational Mereology: A Study of Part-of Relations for Multi-media Indexing, Wlodek Zadrozny and Michelle Kim. (shrink)